The Trial Management Committee (TMC) is responsible for trial conduct and management on a day-to-day basis. TMC membership includes lead and associate investigators, including biostatistician(s), the program manager, the data manager and representatives from the Lived Experience, Māori, and Aboriginal and Torres Strait Islander Committees.

A single PLATIPUS-Data Safety and Monitoring Committee (DSMC) will review the progress of the trial and monitor adherence to the protocol, participant recruitment, outcomes, complications, accuracy and completeness of data capture, and other issues related to participant safety across all regions.

The PLATIPUS Expert Advisory Panel (EAP) will be a group of scientific and content experts with geographic and multidisciplinary representation. The EAP will provide advice and feedback to the TSC about trial conduct, plus domain and intervention prioritisation. They will review trial documents and will have a significant role in site engagement and the dissemination of trial information.

The Statistical Advisory Committee will oversee the statistics side of PLATIPUS. The Committee consists of experts in adaptive platform trials and Bayesian statistician modelling.

The Lived Experience committee will include members who have lived experience of pregnancy/ies at risk of preterm birth, are the parent of a baby born preterm, or were born preterm themselves. The committee will have an active role in all aspects of trial design, prioritisation and implementation.

The Indigenous Health Committee will provide cultural leadership that will inform and contribute to all PLATIPUS trial design and conduct components.

The Pregnancy Domain Committee will develop and respond to priorities for pregnancy research, select and develop pregnancy domains and interventions for the platform, and guide the practical implementation of this research.

The Neonatal Domain Committee will develop and respond to priorities for neonatal research, select and develop neonatal domains and interventions for the platform, and guide the practical implementation of this research.

The Consent and Ethics Working Group investigates ethical issues and guidance for PLATIPUS recruitment processes, including consent.

This working group will design, develop and maintain database systems where information will be stored. The working group will oversee data and database monitoring, security and regulatory compliance.

The Follow-up Working Group investigates how participants in this research will be followed up as they age; i.e. which assessments are helpful, when assessments should take place, etc.

The Health Economics Working Group looks into the health economics component of PLATIPUS, including the cost of pregnancy or special baby care, as well as the benefit to families (quality of life) and the health care system that a change in care might offer.